Reactome | prekallikrein + kininogen -> prekallikrein:kininogen

Schema > Reaction > Entries

prekallikrein + kininogen -> prekallikrein:kininogen Show undefined attributes

authored	[InstanceEdit:9929032] Shamovsky, Veronica, 2024-11-20
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9857940] Shamovsky, Veronica, 2024-01-09
dbId	9857939
displayName	prekallikrein + kininogen -> prekallikrein:kininogen
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
eventOf	[Pathway:R-HSA-9970672] FXIIa activates plasma kallikrein-kinin system - Homo sapiens
followingEvent	[Reaction:R-HSA-9857952] prekallikrein:kininogen binds cell surface receptors - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9857965] KLKB1(20-638) [extracellular region] [EntityWithAccessionedSequence:R-HSA-158125] KNG1(19-644) [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9909037] Identification of prekallikrein and high-molecular-weight kininogen as a complex in human plasma [LiteratureReference:158182] High molecular weight kininogen regulates prekallikrein assembly and activation on endothelial cells: a novel mechanism for contact activation [LiteratureReference:9909028] Studies of binding of prekallikrein and Factor XI to high molecular weight kininogen and its light chain [LiteratureReference:9909038] High molecular weight kininogen interactions with the homologs prekallikrein and factor XI: importance to surface-induced coagulation [LiteratureReference:9857957] Primary structure requirements for the binding of human high molecular weight kininogen to plasma prekallikrein and factor XI [LiteratureReference:9909033] Structures of factor XI and prekallikrein bound to domain 6 of high-molecular weight kininogen reveal alternate domain 6 conformations and exosites
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	prekallikrein + kininogen -> prekallikrein:kininogen KLKB1(20-638) + KNG1(19-644) -> KLKB1(20-638):KNG1(19-644)
orthologousEvent	[Reaction:R-BTA-9857939] prekallikrein + kininogen -> prekallikrein:kininogen - Bos taurus [Reaction:R-GGA-9857939] prekallikrein + kininogen -> prekallikrein:kininogen - Gallus gallus [Reaction:R-XTR-9857939] prekallikrein + kininogen -> prekallikrein:kininogen - Xenopus tropicalis [Reaction:R-SSC-9857939] prekallikrein + kininogen -> prekallikrein:kininogen - Sus scrofa [Reaction:R-CFA-9857939] prekallikrein + kininogen -> prekallikrein:kininogen - Canis familiaris [Reaction:R-RNO-9857939] prekallikrein + kininogen -> prekallikrein:kininogen - Rattus norvegicus [Reaction:R-MMU-9857939] prekallikrein + kininogen -> prekallikrein:kininogen - Mus musculus
output	[Complex:R-HSA-9857934] KLKB1(20-638):KNG1(19-644) [extracellular region]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-03-25
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9980333] Schmaier, Alvin H, 2026-01-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9857939
summation	[Summation:9938548] Plasma prekallikrein (PK, encoded by the KLBK1 gene and depi...

Referrals

(hasEvent)	[Pathway:R-HSA-9970672] FXIIa activates plasma kallikrein-kinin system
(precedingEvent)	[Reaction:R-HSA-9857952] prekallikrein:kininogen binds cell surface receptors