Reactome | Regulation of MITF-M dependent genes involved in invasion

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Regulation of MITF-M dependent genes involved in invasion Show undefined attributes

authored	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
created	[InstanceEdit:9854922] Rothfels, Karen, 2023-11-28
dbId	9854909
displayName	Regulation of MITF-M dependent genes involved in invasion
edited	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
eventOf	[Pathway:R-HSA-9856651] MITF-M-dependent gene expression - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9856062] MITF-M dimer binds the CEACAM1 gene - Homo sapiens [BlackBoxEvent:R-HSA-9856061] MITF-M-dependent CEACAM1 expression - Homo sapiens [Reaction:R-HSA-9857578] MITF-M dimer binds GMPR gene - Homo sapiens [BlackBoxEvent:R-HSA-9857590] MITF-M-dependent GMPR expression - Homo sapiens [Reaction:R-HSA-9857574] MITF-M dimer binds DIAPH1 gene - Homo sapiens [BlackBoxEvent:R-HSA-9857585] MITF-M-dependent DIAPH1 expression - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9732011] MITF is a critical regulator of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in malignant melanoma [LiteratureReference:9857167] Microphthalmia-associated transcription factor suppresses invasion by reducing intracellular GTP pools [LiteratureReference:9857178] Mitf regulation of Dia1 controls melanoma proliferation and invasiveness [LiteratureReference:9730314] SLUG (SNAI2) deletions in patients with Waardenburg disease [LiteratureReference:9854815] Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma [LiteratureReference:9730403] MITF-the first 25 years [LiteratureReference:9731980] Fifteen-year quest for microphthalmia-associated transcription factor target genes [LiteratureReference:9730375] Melanocytes in development, regeneration, and cancer
maxDepth	2
modified	[InstanceEdit:9927682] Rothfels, Karen, 2024-11-08
name	Regulation of MITF-M dependent genes involved in invasion
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26 [InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9854909
summation	[Summation:9857342] Targets of MITF such as CEACAM1, GMPR and DIAPH1 contribute ...
updateTrackers	[UpdateTracker:9911056] Update Tracker - [Pathway:9854909] Regulation of MITF-M dependent genes involved in invasion - v89:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9911056] Update Tracker - [Pathway:9854909] Regulation of MITF-M dependent genes involved in invasion - v89:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-9856651] MITF-M-dependent gene expression