Regulation of MITF-M dependent genes involved in invasion

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R-HSA-9854909
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Pathway
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Homo sapiens
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5/5
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Regulation of MITF-M dependent genes involved in invasion
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Targets of MITF such as CEACAM1, GMPR and DIAPH1 contribute to cellular mobility and invasion by affecting cellular adhesion and regulating the actin cytoskeleton (Ullrich et al, 1995; Bianchi-Smiraglia et al, 2017; Carreira et al, 2006). MITF also regulates expression of genes involved in EMT such as SNAI2 (Sanchez-Martin et al, 2002; Strub et al, 2011). MITF-dependent changes in invasiveness are of particular interest in the context of melanoma (reviewed in Goding and Arnheiter, 2019; Cheli et al, 2010; White and Zon, 2008).
Literature References
PubMed ID Title Journal Year
26301891 MITF is a critical regulator of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in malignant melanoma

Ullrich, N, Davidson, I, Sánchez-Del-Campo, L, Breitenbuecher, F, Horn, S, Zhao, F, Schadendorf, D, Goding, CR, Löffek, S, Helfrich, I, Singer, BB, Ennen, M

Pigment Cell Melanoma Res 2015
12444107 SLUG (SNAI2) deletions in patients with Waardenburg disease

Sánchez-Martín, M, Sánchez-García, I, Read, AP, Sagrera, A, Perez-Losada, J, Rodríguez-García, A

Hum Mol Genet 2002
17182868 Mitf regulation of Dia1 controls melanoma proliferation and invasiveness

Nuciforo, P, Carreira, S, Goodall, J, Rodriguez, M, Goding, CR, Denat, L, Larue, L, Testori, A, Hoek, KS

Genes Dev 2006
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Ye, T, Cormont, M, Keime, C, Kobi, D, Davidson, I, Le Gras, S, Giuliano, S, Bonet, C, Bertolotto, C, Ballotti, R, Strub, T

Oncogene 2011
27181209 Microphthalmia-associated transcription factor suppresses invasion by reducing intracellular GTP pools

Kozlova, NI, Jowdy, P, Moparthy, S, Battaglia, S, Ackroyd, JJ, Lipchick, BC, Foley, CE, Marvin, EK, Shewach, DS, Bianchi-Smiraglia, A, Bagati, A, Fink, EE, Kolesnikova, M, Paul-Rosner, LM, Nikiforov, MA, Wawrzyniak, JA, Bshara, W, Berman, AE

Oncogene 2017
19995375 Fifteen-year quest for microphthalmia-associated transcription factor target genes

Bertolotto, C, Cheli, Y, Ohanna, M, Ballotti, R

Pigment Cell Melanoma Res 2010
31123060 MITF-the first 25 years

Arnheiter, H, Goding, CR

Genes Dev 2019
18786412 Melanocytes in development, regeneration, and cancer

White, RM, Zon, LI

Cell Stem Cell 2008
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Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2023-11-28)
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