Reactome | MITF-M-dependent gene expression

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MITF-M-dependent gene expression Show undefined attributes

authored	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
created	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
dbId	9856651
displayName	MITF-M-dependent gene expression
edited	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
eventOf	[Pathway:R-HSA-9730414] MITF-M-regulated melanocyte development - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-9824585] Regulation of MITF-M-dependent genes involved in pigmentation - Homo sapiens [Pathway:R-HSA-9825892] Regulation of MITF-M-dependent genes involved in cell cycle and proliferation - Homo sapiens [Pathway:R-HSA-9824594] Regulation of MITF-M-dependent genes involved in apoptosis - Homo sapiens [Pathway:R-HSA-9854907] Regulation of MITF-M dependent genes involved in metabolism - Homo sapiens [Pathway:R-HSA-9854909] Regulation of MITF-M dependent genes involved in invasion - Homo sapiens [Pathway:R-HSA-9825895] Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence - Homo sapiens [Pathway:R-HSA-9857377] Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy - Homo sapiens [Pathway:R-HSA-9926550] Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9730403] MITF-the first 25 years [LiteratureReference:9730389] The melanocyte lineage in development and disease [LiteratureReference:9730375] Melanocytes in development, regeneration, and cancer [LiteratureReference:9731980] Fifteen-year quest for microphthalmia-associated transcription factor target genes [LiteratureReference:9855857] Positive and negative elements regulate a melanocyte-specific promoter [LiteratureReference:9855307] Melanocyte-specific expression of the human tyrosinase promoter: activation by the microphthalmia gene product and role of the initiator [LiteratureReference:9856924] Melanocyte-specific gene expression: role of repression and identification of a melanocyte-specific factor, MSF [LiteratureReference:6797648] A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting [LiteratureReference:9856926] Targeting the microphthalmia basic helix-loop-helix-leucine zipper transcription factor to a subset of E-box elements in vitro and in vivo [LiteratureReference:9856932] Transcription activation by Myc and Max: flanking sequences target activation to a subset of CACGTG motifs in vivo [LiteratureReference:9856913] Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers [LiteratureReference:9856922] Local genomic features predict the distinct and overlapping binding patterns of the bHLH-Zip family oncoproteins MITF and MYC-MAX [LiteratureReference:9854815] Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma [LiteratureReference:9926252] MITF reprograms the extracellular matrix and focal adhesion in melanoma [LiteratureReference:9926271] Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition [LiteratureReference:9926258] Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunities
maxDepth	3
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	MITF-M-dependent gene expression
orthologousEvent	[Pathway:R-MMU-9856651] MITF-M-dependent gene expression - Mus musculus [Pathway:R-RNO-9856651] MITF-M-dependent gene expression - Rattus norvegicus [Pathway:R-CFA-9856651] MITF-M-dependent gene expression - Canis familiaris [Pathway:R-BTA-9856651] MITF-M-dependent gene expression - Bos taurus [Pathway:R-SSC-9856651] MITF-M-dependent gene expression - Sus scrofa [Pathway:R-DRE-9856651] MITF-M-dependent gene expression - Danio rerio [Pathway:R-XTR-9856651] MITF-M-dependent gene expression - Xenopus tropicalis [Pathway:R-GGA-9856651] MITF-M-dependent gene expression - Gallus gallus [Pathway:R-DME-9856651] MITF-M-dependent gene expression - Drosophila melanogaster [Pathway:R-CEL-9856651] MITF-M-dependent gene expression - Caenorhabditis elegans
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26 [InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9856651
summation	[Summation:9856896] MITF-M is a transcriptional regulator that is critical for t...
updateTrackers	[UpdateTracker:9928418] Update Tracker - [Pathway:9856651] MITF-M-dependent gene expression - v91:[modifyText, removeHasEvent, removeLiteratureReference] [UpdateTracker:9911064] Update Tracker - [Pathway:9856651] MITF-M-dependent gene expression - v89:[updateContainedPathway, updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-9730414] MITF-M-regulated melanocyte development
(updatedInstance)	[UpdateTracker:9928418] Update Tracker - [Pathway:9856651] MITF-M-dependent gene expression - v91:[modifyText, removeHasEvent, removeLiteratureReference] [UpdateTracker:9911064] Update Tracker - [Pathway:9856651] MITF-M-dependent gene expression - v89:[updateContainedPathway, updateIndirectRLE]

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