Reactome | FIGNL1 binds RAD51

Schema > Reaction > Entries

FIGNL1 binds RAD51 Show undefined attributes

authored	[InstanceEdit:9853378] Orlic-Milacic, Marija, 2023-11-15
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9853378] Orlic-Milacic, Marija, 2023-11-15
dbId	9853389
displayName	FIGNL1 binds RAD51
edited	[InstanceEdit:9909018] Orlic-Milacic, Marija, 2024-04-25
eventOf	[Pathway:R-HSA-5693568] Resolution of D-loop Structures through Holliday Junction Intermediates - Homo sapiens
input	[Complex:R-HSA-9853380] FIRRM:FIGNL1 [nucleoplasm] [Complex:R-HSA-5686228] Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9853366] FIGL1 and its novel partner FLIP form a conserved complex that regulates homologous recombination [LiteratureReference:9853381] FIGNL1-containing protein complex is required for efficient homologous recombination repair
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	FIGNL1 binds RAD51
negativePrecedingEvent	[NegativePrecedingEvent:9910658] Futile Cycle: Ligation of DNA and formation of Holliday structures following repair synthesis
orthologousEvent	[Reaction:R-GGA-9853389] FIGNL1 binds RAD51 - Gallus gallus [Reaction:R-DRE-9853389] FIGNL1 binds RAD51 - Danio rerio [Reaction:R-SSC-9853389] FIGNL1 binds RAD51 - Sus scrofa [Reaction:R-BTA-9853389] FIGNL1 binds RAD51 - Bos taurus [Reaction:R-CFA-9853389] FIGNL1 binds RAD51 - Canis familiaris [Reaction:R-RNO-9853389] FIGNL1 binds RAD51 - Rattus norvegicus [Reaction:R-MMU-9853389] FIGNL1 binds RAD51 - Mus musculus
output	[Complex:R-HSA-9853700] Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:FIRRM:FIGNL1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9853368] FIRRM binds FIGNL1 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9909004] Orthwein, Alexandre, 2024-04-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9853389
summation	[Summation:9853698] FIGNL1 strongly binds to RAD51 and localizes to ionizing rad...

Referrals

(hasEvent)

[Pathway:R-HSA-5693568] Resolution of D-loop Structures through Holliday Junction Intermediates