Reactome | FIGNL1 binds RAD51

FIGNL1 binds RAD51

Stable Identifier

R-HSA-9853389

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Resolution of D-Loop Structures (Homo sapiens)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
        
        FIGNL1 binds RAD51 (Homo sapiens)

General

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FIGNL1 strongly binds to RAD51 and localizes to ionizing radiation-induced DNA damage foci. The interaction involves the N-terminal half of FIGNL1, requiring conserved residues 295-344 called FIGNL1's RAD51 binding domain (FRBD). The efficiency of homologous recombination repair (HRR) is impaired in cells with FIGNL1 depletion (Yuan and Chen 2013). The interaction between FIGNL1 and RAD51 is conserved between human and Arabidopsis. The FIGNL1 binding partner FIRRM (also known as Apolo1 or FLIP or C1orf112) does not directly interact with RAD51 but depletion of either FIRRM or FIGNL1 negatively regulates the formation or the turnover of RAD51 foci in Arabidopsis (Fernandes et al. 2018).

Literature References

PubMed ID	Title	Journal	Year
23754376	FIGNL1-containing protein complex is required for efficient homologous recombination repair Chen, J, Yuan, J	Proc Natl Acad Sci U S A	2013
29608566	FIGL1 and its novel partner FLIP form a conserved complex that regulates homologous recombination Andrey, P, Kumar, R, Froger, N, Seguéla-Arnaud, M, Mercier, R, Choinard, S, Gevaert, K, Fernandes, JB, De Winne, N, Solier, V, Girard, C, Duhamel, M, Grelon, M, De Jaeger, G, Guerois, R	PLoS Genet	2018