p-T,Y MAPK8,9 translocate to the nucleus

Stable Identifier
R-HSA-9851079
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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p-T,Y MAPK8,9 translocate to the nucleus
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After NPM1-ALK-stimulated phosphorylation, MAPK8 and 9 promote activation of nuclear targets such as JUN (Leventaki et al, 2007).
Literature References
PubMed ID Title Journal Year
17416736 NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma

Leventaki, V, Drakos, E, Medeiros, LJ, Lim, MS, Elenitoba-Johnson, KS, Claret, FX, Rassidakis, GZ

Blood 2007
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
anaplastic large cell lymphoma DOID:0050744
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
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