AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter

Stable Identifier
R-HSA-9851064
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter
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STAT3 binds to the promoter of DNMT1 to stimulate gene expression as assessed by chromatin immunoprecipitation (ChIP) and electrophoretic mobility shift assay (EMSA) (Zhang et al, 2006; Ambrogio et al, 2009). In the context of NPM1-ALK signaling in anaplastic large cell leukemia (ALCL), STAT3 signaling also regulates DNMT1 activity by downregulating expression of miR-21, a microRNA that represses translation on DNMT1 mRNA (Zhang et al, 2011).
Literature References
PubMed ID Title Journal Year
19887607 NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells

Ambrogio, C, Martinengo, C, Voena, C, Tondat, F, Riera, L, di Celle, PF, Inghirami, G, Chiarle, R

Cancer Res 2009
21715655 IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK

Zhang, Q, Wang, HY, Liu, X, Bhutani, G, Kantekure, K, Wasik, M

Proc. Natl. Acad. Sci. U.S.A. 2011
16861352 STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes

Zhang, Q, Wang, HY, Woetmann, A, Raghunath, PN, Odum, N, Wasik, MA

Blood 2006
Participants
Input
Output
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as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
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