Reactome | ST8SIA5 transfers Neu5Ac to gangliosides

Schema > Reaction > Entries

ST8SIA5 transfers Neu5Ac to gangliosides Show undefined attributes

authored	[InstanceEdit:9845577] Stephan, Ralf, 2023-10-05
catalystActivity	[CatalystActivity:9845593] alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity of ST8SIA5 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:9845595] Stephan, Ralf, 2023-10-05
dbId	9845587
displayName	ST8SIA5 transfers Neu5Ac to gangliosides
edited	[InstanceEdit:9851336] Stephan, Ralf, 2023-10-23
eventOf	[Pathway:R-HSA-9840309] Glycosphingolipid biosynthesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9850731] Vesicles transport GSL from Golgi to plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-727815] CMP-Neu5Ac [Golgi lumen] [DefinedSet:R-ALL-9845581] GM1b,GD1a,GD3,GT1b [Golgi membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4088000] Molecular cloning and expression of human alpha2,8-sialyltransferase (hST8Sia V) [LiteratureReference:9845583] Molecular cloning and expression of a fifth type of alpha2,8-sialyltransferase (ST8Sia V). Its substrate specificity is similar to that of SAT-V/III, which synthesize GD1c, GT1a, GQ1b and GT3 [LiteratureReference:9845599] Analysis of biochemical features of ST8 ?-N-acetyl-neuraminide ?2,8-sialyltransferase (St8sia) 5 isoforms
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ST8SIA5 transfers Neu5Ac to gangliosides
orthologousEvent	[Reaction:R-GGA-9845587] ST8SIA5 transfers Neu5Ac to gangliosides - Gallus gallus [Reaction:R-XTR-9845587] ST8SIA5 transfers Neu5Ac to gangliosides - Xenopus tropicalis [Reaction:R-SSC-9845587] ST8SIA5 transfers Neu5Ac to gangliosides - Sus scrofa [Reaction:R-BTA-9845587] ST8SIA5 transfers Neu5Ac to gangliosides - Bos taurus [Reaction:R-CFA-9845587] ST8SIA5 transfers Neu5Ac to gangliosides - Canis familiaris [Reaction:R-RNO-9845587] ST8SIA5 transfers Neu5Ac to gangliosides - Rattus norvegicus [Reaction:R-MMU-9845587] ST8SIA5 transfers Neu5Ac to gangliosides - Mus musculus
output	[SimpleEntity:R-ALL-727810] CMP [Golgi lumen] [DefinedSet:R-ALL-9845591] GQ1b,GT3,GD1c,GT1a [Golgi membrane] [SimpleEntity:R-ALL-425969] H+ [Golgi lumen]
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9845587
summation	[Summation:9845588] Alpha-2,8-sialyltransferase 5 (ST8SIA5) transfers N-acetylne...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9850731] Vesicles transport GSL from Golgi to plasma membrane
(hasEvent)	[Pathway:R-HSA-9840309] Glycosphingolipid biosynthesis