Asvasiran binds N mRNA

Stable Identifier
R-HSA-9845192
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
ReviewStatus
5/5
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Asvasiran binds N mRNA
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Asvasiran (ALN-RSV01) is a naked siRNA targeting the RSV nucleocapsid protein. It was safe and efficient in two phase 2 trials, reducing bronchiolitis obliterans syndrome in lung transplant patients infected with RSV (Zamora et al., 2011; Gottlieb et al., 2015). In an earlier phase 2 study, asvasiran reduced the number of infected adult volunteers experimentally inoculated with RSV (DeVincenzo et al., 2010). Asvasiran is applied intranasally or as inhalation (reviewed in Loo et al., 2023).
Literature References
PubMed ID Title Journal Year
20851929 RNA interference therapy in lung transplant patients infected with respiratory syncytial virus

Albert, G, Humar, A, Glanville, AR, Cehelsky, J, Budev, M, DeVincenzo, J, Zamora, MR, Vaishnaw, A, Nochur, S, Gottlieb, J, Rolfe, M, Gollob, JA

Am J Respir Crit Care Med 2011
37186073 Recent Advances in Inhaled Nanoformulations of Vaccines and Therapeutics Targeting Respiratory Viral Infections

Zhou, QT, Loo, CY, Lee, WH

Pharm Res 2023
20421463 A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

Wilkinson, T, Walsh, E, Cehelsky, J, Lambkin-Williams, R, DeVincenzo, J, Vaishnaw, A, Meyers, R, Nochur, S, Gollob, J

Proc Natl Acad Sci U S A 2010
26452996 ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients

Sommerwerk, U, DeVincenzo, J, Zamora, MR, Vaishnaw, A, Nochur, S, Gottlieb, J, Karsten, V, Arcasoy, S, Simon, AR, Dilling, D, Glanville, AR, Hodges, T, Cehelsky, J, Shah, S, Musk, AW, Gollob, J, Bettencourt, BR

J Heart Lung Transplant 2016
Participants
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Output
Participates
as an event of
Disease
Authored
Stephan, R  (2023-09-27)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Stephan, R  (2023-09-28)
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