CLIP1-LTK promotes MAPK1 and MAPK3 phosphorylation

Stable Identifier
R-HSA-9845033
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
3/5
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The CLIP1-LTK fusion promotes phosphorylation of MAPK1 and MAPK3 (ERK1 and ERK2) as assessed by Western blot (Izumi et al, 2021). The mechanism by which the signal is transmitted from the activated receptor to induce MAPK phosphorylation has not yet been elucidated.
Literature References
PubMed ID Title Journal Year
34819663 The CLIP1-LTK fusion is an oncogenic driverĀ in non-small-cell lung cancer

Ikeda, T, Nakachi, I, Watanabe, K, Kodani, M, Hayashi, K, Sakakibara-Konishi, J, Shibata, Y, Nishino, K, Izumi, H, Okamoto, I, Kirita, K, Goto, K, Nosaki, K, Yoh, K, Niho, S, Ishii, G, Matsumoto, S, Kuyama, S, Sakai, T, Liu, J, Furuya, N, Sugiyama, E, Nakai, T, Tanaka, K, Kumagai, S, Yamasaki, A, Daga, H, Zenke, Y, Taima, K, Ebi, N, Hayashida, T, Kato, T, Fukuhara, T, Mori, S, Kobayashi, SS, Udagawa, H, Ohtsu, A, Nakamura, A

Nature 2021
Participants
Participates
This event is regulated
Disease
Name Identifier Synonyms
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Created
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