Reactome | Active LTK phosphorylates IRS1

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Active LTK phosphorylates IRS1 Show undefined attributes

authored	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
catalystActivity	[CatalystActivity:9842630] protein tyrosine kinase activity of Active LTK:IRS1 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9842637] protein tyrosine kinase activity of Active LTK:IRS1 [plasma membrane] Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9842653] Rothfels, Karen, 2023-08-27
dbId	9842666
displayName	Active LTK phosphorylates IRS1
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
eventOf	[Pathway:R-HSA-9842663] Signaling by LTK - Homo sapiens
followingEvent	[Reaction:R-HSA-9842655] IRS1 recruits GRB2 to active LTK - Homo sapiens
input	[Complex:R-HSA-9842600] Active LTK:IRS1 [plasma membrane] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9842446] Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus [LiteratureReference:9842473] Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Active LTK phosphorylates IRS1
orthologousEvent	[Reaction:R-GGA-9842666] Active LTK phosphorylates IRS1 - Gallus gallus [Reaction:R-XTR-9842666] Active LTK phosphorylates IRS1 - Xenopus tropicalis [Reaction:R-DRE-9842666] Active LTK phosphorylates IRS1 - Danio rerio [Reaction:R-RNO-9842666] Active LTK phosphorylates IRS1 - Rattus norvegicus [Reaction:R-MMU-9842666] Active LTK phosphorylates IRS1 - Mus musculus
output	[Complex:R-HSA-9842601] Active LTK:p-Y IRS1 [plasma membrane] [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-9842671] Active LTK binds IRS1 - Homo sapiens
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9842666
summation	[Summation:9842647] In the context of a chimeric EGFR-LTK receptor, IRS1 is phos...

Referrals

(hasEvent)	[Pathway:R-HSA-9842663] Signaling by LTK
(precedingEvent)	[Reaction:R-HSA-9842655] IRS1 recruits GRB2 to active LTK

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