Reactome | Active LTK phosphorylates IRS1

Active LTK phosphorylates IRS1

Stable Identifier

R-HSA-9842666

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

3/5

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In the context of a chimeric EGFR-LTK receptor, IRS1 is phosphorylated after stimulation with EGF (Ueno et al, 1995; Ueno et al, 1996). Phosphorylated IRS1 appears to contribute to MAPK signaling by the chimeric receptor by recruiting GRB2; abrogation of the IRS1 tyrosine binding site on the LTK receptor decreases phosphorylation of MAPK1 and MAPK3 and mitogenic activity in BaF3 cells (Ueno et al, 1995; Ueno et al, 1996).

Literature References

PubMed ID	Title	Journal	Year
8910363	Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase Ueno, H, Sasaki, K, Kozutsumi, H, Miyagawa, K, Mitani, K, Yazaki, Y, Hirai, H	J Biol Chem	1996
14695357	Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus Li, N, Nakamura, K, Jiang, Y, Tsurui, H, Matsuoka, S, Abe, M, Ohtsuji, M, Nishimura, H, Kato, K, Kawai, T, Atsumi, T, Koike, T, Shirai, T, Ueno, H, Hirose, S	Hum Mol Genet	2004