Active LTK phosphorylates IRS1

Stable Identifier
R-HSA-9842666
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
3/5
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In the context of a chimeric EGFR-LTK receptor, IRS1 is phosphorylated after stimulation with EGF (Ueno et al, 1995; Ueno et al, 1996). Phosphorylated IRS1 appears to contribute to MAPK signaling by the chimeric receptor by recruiting GRB2; abrogation of the IRS1 tyrosine binding site on the LTK receptor decreases phosphorylation of MAPK1 and MAPK3 and mitogenic activity in BaF3 cells (Ueno et al, 1995; Ueno et al, 1996).
Literature References
PubMed ID Title Journal Year
8910363 Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase

Yazaki, Y, Mitani, K, Miyagawa, K, Kozutsumi, H, Hirai, H, Sasaki, K, Ueno, H

J Biol Chem 1996
14695357 Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus

Jiang, Y, Shirai, T, Matsuoka, S, Li, N, Tsurui, H, Koike, T, Ueno, H, Atsumi, T, Kawai, T, Ohtsuji, M, Hirose, S, Nishimura, H, Kato, K, Abe, M, Nakamura, K

Hum Mol Genet 2004
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of Active LTK:IRS1 [plasma membrane]

Orthologous Events
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