In the context of a chimeric EGFR-LTK receptor, IRS1 is phos...

created [InstanceEdit:9842653] Rothfels, Karen, 2023-08-27
dbId 9842647
displayName In the context of a chimeric EGFR-LTK receptor, IRS1 is phos...
modified [InstanceEdit:9845075] Rothfels, Karen, 2023-09-26
schemaClass Summation
text In the context of a chimeric EGFR-LTK receptor, IRS1 is phosphorylated after stimulation with EGF (Ueno et al, 1995; Ueno et al, 1996). Phosphorylated IRS1 appears to contribute to MAPK signaling by the chimeric receptor by recruiting GRB2; abrogation of the IRS1 tyrosine binding site on the LTK receptor decreases phosphorylation of MAPK1 and MAPK3 and mitogenic activity in BaF3 cells (Ueno et al, 1995; Ueno et al, 1996).
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