Reactome | Active LTK receptor binds SHC1

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Active LTK receptor binds SHC1 Show undefined attributes

authored	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9842653] Rothfels, Karen, 2023-08-27
dbId	9842641
displayName	Active LTK receptor binds SHC1
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
eventOf	[Pathway:R-HSA-9842663] Signaling by LTK - Homo sapiens
followingEvent	[Reaction:R-HSA-9842651] Active LTK receptor phosphorylates SHC1 - Homo sapiens
input	[Complex:R-HSA-9842590] p-5Y LTK dimer:ALKAL1,2 [plasma membrane] [CandidateSet:R-HSA-9842599] SHC1-1,SHC1-2,SHC1-3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9842507] An epidermal growth factor receptor-leukocyte tyrosine kinase chimeric receptor generates ligand-dependent growth signals through the Ras signaling pathway [LiteratureReference:9842473] Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase [LiteratureReference:9842427] The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase [LiteratureReference:9842439] Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth [LiteratureReference:9842429] ALK-activating homologous mutations in LTK induce cellular transformation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Active LTK receptor binds SHC1
orthologousEvent	[Reaction:R-GGA-9842641] Active LTK receptor binds SHC1 - Gallus gallus [Reaction:R-RNO-9842641] Active LTK receptor binds SHC1 - Rattus norvegicus [Reaction:R-MMU-9842641] Active LTK receptor binds SHC1 - Mus musculus
output	[Complex:R-HSA-9842592] Active LTK:SHC1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9842648] Autophosphorylation of LTK dimer:ALKAL1,2 - Homo sapiens
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9842641
summation	[Summation:9842642] Active LTK appears to interact with SHC proteins through tyr...

Referrals

(precedingEvent)	[Reaction:R-HSA-9842651] Active LTK receptor phosphorylates SHC1
(hasEvent)	[Pathway:R-HSA-9842663] Signaling by LTK