Reactome | Active LTK receptor binds SHC1

Active LTK receptor binds SHC1

Stable Identifier

R-HSA-9842641

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

3/5

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Active LTK appears to interact with SHC proteins through tyrosine 862 in an NPXY motif near the receptor C-terminus (Ueno et al, 1995; Ueno et al, 1996; Ueno et al, 1997). In the context of a chimeric EGFR-LTK receptor, the p46, p52 and p66 isoforms of SHC1 were co-precipitated with the receptor, GRB2 and SOS1 (Ueno et al, 1995). Signaling through the SHC1:GRB2:SOS pathway promotes activation of the MAPK signaling pathway, including phosphorylation of MAPK1 and MAPK3, and contributes to mitogenic cues (Ueno et al, 1995; Yamada et al, 2008; Roll and Reuther, 2012).

Literature References

PubMed ID	Title	Journal	Year
8910363	Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase Ueno, H, Sasaki, K, Kozutsumi, H, Miyagawa, K, Mitani, K, Yazaki, Y, Hirai, H	J Biol Chem	1996
9223670	The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase Ueno, H, Honda, H, Nakamoto, T, Yamagata, T, Sasaki, K, Miyagawa, K, Mitani, K, Yazaki, Y, Hirai, H	Oncogene	1997
7650032	An epidermal growth factor receptor-leukocyte tyrosine kinase chimeric receptor generates ligand-dependent growth signals through the Ras signaling pathway Ueno, H, Hirano, N, Kozutsumi, H, Sasaki, K, Tanaka, T, Yazaki, Y, Hirai, H	J Biol Chem	1995
22347506	ALK-activating homologous mutations in LTK induce cellular transformation Roll, JD, Reuther, GW	PLoS One	2012
18849880	Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth Yamada, S, Nomura, T, Takano, K, Fujita, S, Miyake, M, Miyake, J	Neuroreport	2008