Reactome | bHEXA,bHEXS hydrolyze GM2A:SM2

Schema > Reaction > Entries

bHEXA,bHEXS hydrolyze GM2A:SM2 Show undefined attributes

authored	[InstanceEdit:9840856] Stephan, Ralf, 2023-07-30
catalystActivity	[CatalystActivity:9840888] beta-N-acetylhexosaminidase activity of bHEXA,bHEXS [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:9840892] Stephan, Ralf, 2023-08-01
dbId	9840884
displayName	bHEXA,bHEXS hydrolyze GM2A:SM2
edited	[InstanceEdit:9842093] Stephan, Ralf, 2023-08-17
eventOf	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9840949] ARSA removes sulfate from SM3 - Homo sapiens [Reaction:R-HSA-1605717] GM2A binds and mobilizes ligands - Homo sapiens
input	[Complex:R-HSA-9840882] GM2A:SM2 [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9840889] Physiological substrates for human lysosomal beta -hexosaminidase S
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	bHEXA,bHEXS hydrolyze GM2A:SM2
orthologousEvent	[Reaction:R-CEL-9840884] bHEXA,bHEXS hydrolyze GM2A:SM2 - Caenorhabditis elegans [Reaction:R-GGA-9840884] bHEXA,bHEXS hydrolyze GM2A:SM2 - Gallus gallus [Reaction:R-DRE-9840884] bHEXA,bHEXS hydrolyze GM2A:SM2 - Danio rerio [Reaction:R-SSC-9840884] bHEXA,bHEXS hydrolyze GM2A:SM2 - Sus scrofa [Reaction:R-BTA-9840884] bHEXA,bHEXS hydrolyze GM2A:SM2 - Bos taurus [Reaction:R-CFA-9840884] bHEXA,bHEXS hydrolyze GM2A:SM2 - Canis familiaris [Reaction:R-RNO-9840884] bHEXA,bHEXS hydrolyze GM2A:SM2 - Rattus norvegicus [Reaction:R-MMU-9840884] bHEXA,bHEXS hydrolyze GM2A:SM2 - Mus musculus
output	[SimpleEntity:R-ALL-1605658] GalNAc [lysosomal lumen] [EntityWithAccessionedSequence:R-HSA-1605614] GM2A(32-193) [lysosomal lumen] [SimpleEntity:R-ALL-9840879] SM3 [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-1605717] GM2A binds and mobilizes ligands - Homo sapiens
regulatedBy	[Requirement:9840876] Requirement by 'BMP [multivesicular body, internal vesicle membrane]'
regulationReference	[RegulationReference:9840877] Requirement by 'BMP [multivesicular body, internal vesicle membrane]' Physiological substrates for human lysosomal beta -hexosaminidase S
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9842059] D'Eustachio, Peter, 2023-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9840884
summation	[Summation:9840887] The beta-hexosaminidase isoforms A (bHEXA) and S (bHEXS) con...
updateTrackers	[UpdateTracker:9853261] Update Tracker - [Reaction:9840884] bHEXA,bHEXS hydrolyze GM2A:SM2 - v87:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9853261] Update Tracker - [Reaction:9840884] bHEXA,bHEXS hydrolyze GM2A:SM2 - v87:[modifyText]
(hasEvent)	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism
(precedingEvent)	[Reaction:R-HSA-9840949] ARSA removes sulfate from SM3 [Reaction:R-HSA-1605717] GM2A binds and mobilizes ligands