Reactome | GM2A binds and mobilizes ligands

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GM2A binds and mobilizes ligands Show undefined attributes

authored	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
catalystActivity	[CatalystActivity:1861790] sphingolipid activator protein activity of GM2A(32-193) [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen [Compartment:3828048] multivesicular body, internal vesicle membrane
created	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
dbId	1605717
displayName	GM2A binds and mobilizes ligands
edited	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
eventOf	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9840795] Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 - Homo sapiens [Reaction:R-HSA-1605595] bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 - Homo sapiens [Reaction:R-HSA-9840884] bHEXA,bHEXS hydrolyze GM2A:SM2 - Homo sapiens [Reaction:R-HSA-1605624] Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 - Homo sapiens
input	[DefinedSet:R-ALL-9840941] GM2A ligands [multivesicular body, internal vesicle membrane] [EntityWithAccessionedSequence:R-HSA-1605614] GM2A(32-193) [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1605692] Structural analysis of lipid complexes of GM2-activator protein [LiteratureReference:1605738] A mutation in the gene of a glycolipid-binding protein (GM2 activator) that causes GM2-gangliosidosis variant AB [LiteratureReference:9840460] Degradation of membrane-bound ganglioside GM1. Stimulation by bis(monoacylglycero)phosphate and the activator proteins SAP-B and GM2-AP [LiteratureReference:9840312] Emerging concepts of ganglioside metabolism
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	GM2A binds and mobilizes ligands
orthologousEvent	[Reaction:R-XTR-1605717] GM2A binds and mobilizes ligands - Xenopus tropicalis [Reaction:R-CEL-1605717] GM2A binds and mobilizes ligands - Caenorhabditis elegans [Reaction:R-GGA-1605717] GM2A binds and mobilizes ligands - Gallus gallus [Reaction:R-DRE-1605717] GM2A binds and mobilizes ligands - Danio rerio [Reaction:R-SSC-1605717] GM2A binds and mobilizes ligands - Sus scrofa [Reaction:R-BTA-1605717] GM2A binds and mobilizes ligands - Bos taurus [Reaction:R-CFA-1605717] GM2A binds and mobilizes ligands - Canis familiaris [Reaction:R-RNO-1605717] GM2A binds and mobilizes ligands - Rattus norvegicus [Reaction:R-MMU-1605717] GM2A binds and mobilizes ligands - Mus musculus
output	[Complex:R-HSA-9840631] GM2A:Ligands [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-1605595] bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 - Homo sapiens [BlackBoxEvent:R-HSA-9840579] GM1 localizes to ILV membrane - Homo sapiens [Reaction:R-HSA-9840884] bHEXA,bHEXS hydrolyze GM2A:SM2 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1863068] Stephan, Ralf, 2011-10-31 [InstanceEdit:9842094] D'Eustachio, Peter, 2023-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1605717
summation	[Summation:9840630] Ganglioside GM2 activator (GM2A, GM2AP) acts as carrier prot...
updateTrackers	[UpdateTracker:9842323] Update Tracker - [Reaction:1605717] GM2A binds and mobilizes ligands - v86:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeSummation]

Referrals

(updatedInstance)	[UpdateTracker:9842323] Update Tracker - [Reaction:1605717] GM2A binds and mobilizes ligands - v86:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeSummation]
(precedingEvent)	[Reaction:R-HSA-9840795] Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 [Reaction:R-HSA-1605595] bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 [Reaction:R-HSA-1605624] Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 [Reaction:R-HSA-9840884] bHEXA,bHEXS hydrolyze GM2A:SM2
(hasEvent)	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism

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