Reactome | HIV TAR RNA binds PKR

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HIV TAR RNA binds PKR Show undefined attributes

authored	[InstanceEdit:9841883] Stephan, Ralf, 2023-08-15
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9839024] Stephan, Ralf, 2023-06-29
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	9839025
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	HIV TAR RNA binds PKR
edited	[InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
eventOf	[Pathway:R-HSA-9833482] PKR-mediated signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-168699] EIF2AK2 [cytosol] [GenomeEncodedEntity:R-HIV-9842175] HIV TAR RNA [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9835959] Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA-activated protein kinase [LiteratureReference:9835993] The Regulatory and Kinase Domains but Not the Interdomain Linker Determine Human Double-stranded RNA-activated Kinase (PKR) Sensitivity to Inhibition by Viral Non-coding RNAs
maxDepth	1
modified	[InstanceEdit:9937069] Stephan, Ralf, 2025-01-29
name	HIV TAR RNA binds PKR
output	[Complex:R-HSA-9839021] EIF2AK2:HIV TAR RNA [cytosol]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9841953] Patel, Rekha C, 2023-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9839025
summation	[Summation:9839023] The Tat-responsive region (TAR) RNA sequence from human immu...

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[Pathway:R-HSA-9833482] PKR-mediated signaling

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