Reactome | HIV TAR RNA binds PKR

HIV TAR RNA binds PKR

Stable Identifier

R-HSA-9839025

Type

Reaction [binding]

Species

Homo sapiens

Related Species

Human immunodeficiency virus 1

Compartment

cytosol

ReviewStatus

5/5

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The Tat-responsive region (TAR) RNA sequence from human immunodeficiency virus (HIV) is <30bp long and present as part of all HIV mRNAs at their 5' end, and in a free cytoplasmic form. This region also inhibits PKR, sustaining translation of viral proteins during infection (Gunnery et al, 1990; Sanghvi et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
26432638	The Regulatory and Kinase Domains but Not the Interdomain Linker Determine Human Double-stranded RNA-activated Kinase (PKR) Sensitivity to Inhibition by Viral Non-coding RNAs Schwartz, SL, Sunita, S, Conn, GL	J Biol Chem	2015
2247437	Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA-activated protein kinase Gunnery, S, Robertson, HD, Mathews, MB, Rice, AP	Proc Natl Acad Sci U S A	1990

Participants

Input

Output

EIF2AK2:HIV TAR RNA [cytosol] (Homo sapiens)

Participates

as an event of

PKR-mediated signaling (Homo sapiens)

Disease

Name	Identifier	Synonyms
Human immunodeficiency virus infectious disease	DOID:526	HIV infection

Authored

Stephan, R (2023-08-15)

Reviewed

Patel, RC (2023-08-16)

Created

Stephan, R (2023-06-29)

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