Reactome | GRSF1 unwinds quadruplex G regions in RNA

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GRSF1 unwinds quadruplex G regions in RNA Show undefined attributes

authored	[InstanceEdit:9836950] May, Bruce, 2023-06-06
catalystActivity	[CatalystActivity:9837646] G-quadruplex RNA binding activity of GRSF1:MT-ND6 mRNA, antisense MT-CYB, MT-ND4, MT-ND5 with quadruplex G [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9836992] May, Bruce, 2023-06-07
dbId	9836998
displayName	GRSF1 unwinds quadruplex G regions in RNA
edited	[InstanceEdit:9836950] May, Bruce, 2023-06-06
eventOf	[Pathway:R-HSA-9836573] Mitochondrial RNA degradation - Homo sapiens
input	[Complex:R-HSA-9837008] GRSF1:MT-ND6 mRNA, antisense MT-CYB, MT-ND4, MT-ND5 with quadruplex G [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9836985] Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria [LiteratureReference:9837009] The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression
maxDepth	1
modified	[InstanceEdit:9841153] May, Bruce, 2023-08-09
name	GRSF1 unwinds quadruplex G regions in RNA
output	[EntityWithAccessionedSequence:R-HSA-9837006] GRSF1 [mitochondrial matrix] [DefinedSet:R-HSA-9836987] MT-ND6 mRNA, antisense MT-CYB, MT-ND4, MT-ND5 RNA [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-9836993] GRSF1 binds RNA containing quadruplex guanosine - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9841151] Anonymous, Reviewer, 2023-08-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9836998
summation	[Summation:9837245] GRSF1 binds regions of quadruplex G structures in specific G...

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(hasEvent)

[Pathway:R-HSA-9836573] Mitochondrial RNA degradation

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