Reactome | Mitochondrial RNA degradation

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Mitochondrial RNA degradation Show undefined attributes

authored	[InstanceEdit:9836595] May, Bruce, 2023-05-28
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9836591] May, Bruce, 2023-05-30
dbId	9836573
displayName	Mitochondrial RNA degradation
edited	[InstanceEdit:9836595] May, Bruce, 2023-05-28
eventOf	[TopLevelPathway:R-HSA-8953854] Metabolism of RNA - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:358040] mitochondrial RNA catabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9836993] GRSF1 binds RNA containing quadruplex guanosine - Homo sapiens [Reaction:R-HSA-9836998] GRSF1 unwinds quadruplex G regions in RNA - Homo sapiens [Reaction:R-HSA-9836927] SUPV3L1 unwinds double-stranded mitochondiral RNA - Homo sapiens [Reaction:R-HSA-9836585] SUPV3L1:PNPT1 hydrolyzes mitochondrial RNA to yield 4-5 nucleotide oligoribonucleotides - Homo sapiens [Reaction:R-HSA-9836822] REXO2 hydrolyzes 4-5 nucleotide RNAs to ribonucleotides - Homo sapiens [Reaction:R-HSA-9837034] SLIRP:LRPPRC binds mitochondrial RNAs - Homo sapiens [Pathway:R-HSA-9837092] FASTK family proteins regulate processing and stability of mitochondrial RNAs - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9836939] Controlling the mitochondrial antisense - role of the SUV3-PNPase complex and its co-factor GRSF1 in mitochondrial RNA surveillance [LiteratureReference:6787374] The human mitochondrial transcriptome [LiteratureReference:9837284] Transcription, Processing, and Decay of Mitochondrial RNA in Health and Disease [LiteratureReference:9837325] RNA turnover in human mitochondria: more questions than answers? [LiteratureReference:9837322] Human Mitochondrial RNA Processing and Modifications: Overview [LiteratureReference:6798648] The post-transcriptional life of mammalian mitochondrial RNA [LiteratureReference:6792957] Mitochondrial transcript maturation and its disorders [LiteratureReference:9837009] The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression [LiteratureReference:9836985] Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria [LiteratureReference:9836838] Human REXO2 controls short mitochondrial RNAs generated by mtRNA processing and decay machinery to prevent accumulation of double-stranded RNA [LiteratureReference:9836831] REXO2 is an oligoribonuclease active in human mitochondria [LiteratureReference:9836940] Purified human SUV3p exhibits multiple-substrate unwinding activity upon conformational change [LiteratureReference:9836579] Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality [LiteratureReference:9837246] Crystal structure of human polynucleotide phosphorylase: insights into its domain function in RNA binding and degradation [LiteratureReference:9837048] LRPPRC and SLIRP interact in a ribonucleoprotein complex that regulates posttranscriptional gene expression in mitochondria [LiteratureReference:9837047] LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria [LiteratureReference:9837036] LRPPRC-mediated folding of the mitochondrial transcriptome [LiteratureReference:9837088] The FASTK family of proteins: emerging regulators of mitochondrial RNA biology [LiteratureReference:9837373] Mitochondrial Gene Expression and Beyond-Novel Aspects of Cellular Physiology [LiteratureReference:9840863] Organization and expression of the mammalian mitochondrial genome [LiteratureReference:9840866] Long noncoding RNAs are generated from the mitochondrial genome and regulated by nuclear-encoded proteins [LiteratureReference:9840865] LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs
maxDepth	3
modified	[InstanceEdit:9841153] May, Bruce, 2023-08-09
name	Mitochondrial RNA degradation
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9841151] Anonymous, Reviewer, 2023-08-09
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9836573
summation	[Summation:9837075] The human mitochondrial genome encodes two rRNAs, 22 tRNAs, ...

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[TopLevelPathway:R-HSA-8953854] Metabolism of RNA

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