GRSF1 binds regions of quadruplex G structures in specific G...

created [InstanceEdit:9837249] May, Bruce, 2023-06-11
dbId 9837245
displayName GRSF1 binds regions of quadruplex G structures in specific G...
literatureReference
modified [InstanceEdit:9837650] May, Bruce, 2023-06-16
schemaClass Summation
text GRSF1 binds regions of quadruplex G structures in specific G-rich mitochondrial mRNAs (Antonicka et al. 2013, Pietras et al. 2018) and melts the quadruplex structure to allow degradation of the resulting unstructured RNA by the SUPV3L1:PNPT1 complex, also called the degradosome (Pietras et al. 2018). GRSF1 and SUPV3L1:PNPT1 interact via the substrate RNA rather than via protein-protein interactions (Pietras et al. 2018). GRSF1 also interacts with RNase P to participate in RNA processing (Jourdain et al. 2013).
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