Reactome | The Immunoglobulin of the BCR binds antigen

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The Immunoglobulin of the BCR binds antigen Show undefined attributes

authored	[InstanceEdit:983698] May, B, 2010-09-28
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:983694] May, B, 2010-11-02
dbId	983696
displayName	The Immunoglobulin of the BCR binds antigen
edited	[InstanceEdit:983698] May, B, 2010-09-28
eventOf	[Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9606883] CD19 is phosphorylated - Homo sapiens [Reaction:R-HSA-983709] LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) - Homo sapiens
input	[OtherEntity:R-ALL-983667] Antigen [extracellular region] [Complex:R-HSA-983677] BCR [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1169008] Occurrence of surface IgM, IgD, and free light chains of human lymphocytes [LiteratureReference:1169010] Similar idiotypic specificity for the membrane IgD and IgM of human B lymphocytes [LiteratureReference:1169061] Surface markers of human lymphocytes [LiteratureReference:983499] Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement [LiteratureReference:1169035] Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking [LiteratureReference:1168960] Comparison of human B cell antigen receptor complexes: membrane-expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers [LiteratureReference:983507] Reconstitution of the B cell antigen receptor signaling components in COS cells [LiteratureReference:1168982] Enhanced tyrosine phosphorylation in B lymphocytes upon complexing of membrane immunoglobulin [LiteratureReference:1169080] Early events in B cell activation [LiteratureReference:2033020] Molecular components of the B cell antigen receptor complex of class IgD differ partly from those of IgM [LiteratureReference:2033039] Molecular components of the B-cell antigen receptor complex of the IgM class
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	The Immunoglobulin of the BCR binds antigen The Immunoglobulin of the B Cell Receptor Binds Antigen
orthologousEvent	[Reaction:R-SSC-983696] The Immunoglobulin of the BCR binds antigen - Sus scrofa [Reaction:R-BTA-983696] The Immunoglobulin of the BCR binds antigen - Bos taurus [Reaction:R-CFA-983696] The Immunoglobulin of the BCR binds antigen - Canis familiaris [Reaction:R-RNO-983696] The Immunoglobulin of the BCR binds antigen - Rattus norvegicus [Reaction:R-MMU-983696] The Immunoglobulin of the BCR binds antigen - Mus musculus
output	[Complex:R-HSA-983689] Antigen:BCR [plasma membrane]
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2108988] Wienands, J, 2012-02-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-983696
summation	[Summation:1168933] Mature, unstimulated B cells express IgM and IgD immunoglobu...

Referrals

(hasEvent)	[Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
(precedingEvent)	[BlackBoxEvent:R-HSA-9606883] CD19 is phosphorylated [Reaction:R-HSA-983709] LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)

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