The Immunoglobulin of the BCR binds antigen

Stable Identifier
R-HSA-983696
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
The Immunoglobulin of the B Cell Receptor Binds Antigen
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Mature, unstimulated B cells express IgM and IgD immunoglobulins on their surfaces (Fu et al. 1974, Fu et al. 1975, reviewed in Kunkel 1975). The immunoglobulins form B cell receptor (BCR) complexes with disulfide-linked heterodimers of Ig-alpha (CD79A) and Ig-beta (CD79B), which have cytoplasmic tails containing immunoreceptor tyrosine-based activation motifs (ITAMs) (van Noesel et al. 1992, Saouaf et al. 1995, inferred from mouse Hombach et al. 1990, Wienands et al. 1990). Upon binding of antigen to the immunoglobulin a chain of phosphorylation events is triggered (Nel et al. 1984, Saouaf et al. 1994, Hata et al. 1994, Saouaf et al. 1995, reviewed in Harwood and Batista 2010).

Literature References
PubMed ID Title Journal Year
7927516 Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking

Hata, D, Nakamura, T, Kawakami, T, Kawakami, Y, Herren, B, Mayumi, M

Immunol Lett 1994
7592958 Reconstitution of the B cell antigen receptor signaling components in COS cells

Saouaf, SJ, Kut, SA, Fargnoli, J, Rowley, RB, Bolen, JB, Mahajan, S

J Biol Chem 1995
20192804 Early events in B cell activation

Harwood, NE, Batista, FD

Annu Rev Immunol 2010
6335036 Enhanced tyrosine phosphorylation in B lymphocytes upon complexing of membrane immunoglobulin

Nel, AE, Landreth, GE, Goldschmidt-Clermont, PJ, Tung, HE, Galbraith, RM

Biochem Biophys Res Commun 1984
7524079 Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement

Saouaf, SJ, Mahajan, S, Rowley, RB, Kut, SA, Fargnoli, J, Burkhardt, AL, Tsukada, S, Witte, ON, Bolen, JB

Proc Natl Acad Sci U S A 1994
1081164 Surface markers of human lymphocytes

Kunkel, HG

Johns Hopkins Med J 1975
2303036 Molecular components of the B cell antigen receptor complex of class IgD differ partly from those of IgM

Wienands, J, Hombach, J, Radbruch, A, Riesterer, C, Reth, M

EMBO J 1990
803528 Similar idiotypic specificity for the membrane IgD and IgM of human B lymphocytes

Fu, SM, Winchester, RJ, Kunkel, HG

J Immunol 1975
1375264 Comparison of human B cell antigen receptor complexes: membrane-expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers

Van Noesel, CJ, Brouns, GS, van Schijndel, GM, Bende, RJ, Mason, DY, Borst, J, van Lier, RA

J Exp Med 1992
4589993 Occurrence of surface IgM, IgD, and free light chains of human lymphocytes

Fu, SM, Winchester, RJ, Kunkel, HG

J Exp Med 1974
2304550 Molecular components of the B-cell antigen receptor complex of the IgM class

Hombach, J, Tsubata, T, Leclercq, L, Stappert, H, Reth, M

Nature 1990
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