Reactome | p-PKR dimer phosphorylates PPP2R5A

Schema > Reaction > Entries

p-PKR dimer phosphorylates PPP2R5A Show undefined attributes

authored	[InstanceEdit:9836614] Stephan, Ralf, 2023-05-31
catalystActivity	[CatalystActivity:9835964] protein kinase activity of p-EIF2AK2 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9836648] Stephan, Ralf, 2023-06-01
dbId	9836664
displayName	p-PKR dimer phosphorylates PPP2R5A
edited	[InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
eventOf	[Pathway:R-HSA-9833482] PKR-mediated signaling - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9836650] PPP2R5A-specific PP2A [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9836654] The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells [LiteratureReference:9836651] The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR [LiteratureReference:9836649] PPP2R5A: A multirole protein phosphatase subunit in regulating cancer development [LiteratureReference:9836652] PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	p-PKR dimer phosphorylates PPP2R5A
orthologousEvent	[Reaction:R-DDI-9836664] p-PKR dimer phosphorylates PPP2R5A - Dictyostelium discoideum [Reaction:R-CEL-9836664] p-PKR dimer phosphorylates PPP2R5A - Caenorhabditis elegans [Reaction:R-DME-9836664] p-PKR dimer phosphorylates PPP2R5A - Drosophila melanogaster [Reaction:R-XTR-9836664] p-PKR dimer phosphorylates PPP2R5A - Xenopus tropicalis [Reaction:R-SSC-9836664] p-PKR dimer phosphorylates PPP2R5A - Sus scrofa [Reaction:R-BTA-9836664] p-PKR dimer phosphorylates PPP2R5A - Bos taurus [Reaction:R-CFA-9836664] p-PKR dimer phosphorylates PPP2R5A - Canis familiaris [Reaction:R-RNO-9836664] p-PKR dimer phosphorylates PPP2R5A - Rattus norvegicus [Reaction:R-MMU-9836664] p-PKR dimer phosphorylates PPP2R5A - Mus musculus
output	[Complex:R-HSA-9836662] Activated PPP2R5A-specific PP2A [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-9833820] PKR dimer autophosphorylates - Homo sapiens
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9841953] Patel, Rekha C, 2023-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9836664
summation	[Summation:9836668] PPP2R5A, as a subunit of the phosphatase PP2A complex, can r...

Referrals

(hasEvent)

[Pathway:R-HSA-9833482] PKR-mediated signaling