Reactome | p-PKR dimer phosphorylates PPP2R5A

p-PKR dimer phosphorylates PPP2R5A

Stable Identifier

R-HSA-9836664

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PPP2R5A, as a subunit of the phosphatase PP2A complex, can regulate the cellular location, substrate specification, and protein phosphatase function of PP2A. Protein kinase R (PKR, EIF2AK2) phosphorylates PPP2R5A at S28, which results in mitochondrial localization of PPP2R5A and activation of the PP2A holoenzyme. In contrast, silencing PKR significantly suppressed the activity of PP2A. PP2A activation supports apoptotic processes that likely include inactivation of BCL2 by dephosphorylation (Xu & Williams, 2000; Ruvolo et al, 2008; Yang et al, 2010; reviewed by Mao et al, 2018).

Literature References

PubMed ID	Title	Journal	Year
29175459	PPP2R5A: A multirole protein phosphatase subunit in regulating cancer development Su, C, Sun, B, Lin, X, Mao, Z, Liu, C	Cancer Lett	2018
10866685	The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR Williams, BR, Xu, Z	Mol Cell Biol	2000
18957415	PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells Ruvolo, VR, Schuster, TF, Ruvolo, PP, Karanjeet, KB, Martelli, AM, Kurinna, SM, McCubrey, JA	J Biol Chem	2008
20685959	The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells Opperman, MJ, Yang, X, Chan, C, Nath, A	Mol Biol Cell	2010