Reactome | SPHK1 binds PKR

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SPHK1 binds PKR Show undefined attributes

authored	[InstanceEdit:9836545] Stephan, Ralf, 2023-05-30
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9836610] Stephan, Ralf, 2023-05-31
dbId	9836606
displayName	SPHK1 binds PKR
edited	[InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
eventOf	[Pathway:R-HSA-9833482] PKR-mediated signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-168699] EIF2AK2 [cytosol] [EntityWithAccessionedSequence:R-HSA-5218716] p-S225-SPHK1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9836556] Cell fate determined by the activation balance between PKR and SPHK1
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	SPHK1 binds PKR
orthologousEvent	[Reaction:R-DDI-9836606] SPHK1 binds PKR - Dictyostelium discoideum [Reaction:R-CEL-9836606] SPHK1 binds PKR - Caenorhabditis elegans [Reaction:R-DME-9836606] SPHK1 binds PKR - Drosophila melanogaster [Reaction:R-GGA-9836606] SPHK1 binds PKR - Gallus gallus [Reaction:R-XTR-9836606] SPHK1 binds PKR - Xenopus tropicalis [Reaction:R-SSC-9836606] SPHK1 binds PKR - Sus scrofa [Reaction:R-BTA-9836606] SPHK1 binds PKR - Bos taurus [Reaction:R-CFA-9836606] SPHK1 binds PKR - Canis familiaris [Reaction:R-RNO-9836606] SPHK1 binds PKR - Rattus norvegicus [Reaction:R-MMU-9836606] SPHK1 binds PKR - Mus musculus
output	[Complex:R-HSA-9836608] EIF2AK2:p-SPHK1 [cytosol]
precedingEvent	[Reaction:R-HSA-5218823] PKC phosphorylates sphingosine kinase 1 - Homo sapiens
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9841953] Patel, Rekha C, 2023-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9836606
summation	[Summation:9836609] Sphingosine kinase 1 (SPHK1) that has been phosphorylated at...

Referrals

(hasEvent)

[Pathway:R-HSA-9833482] PKR-mediated signaling