Reactome | SPHK1 binds PKR

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10094165
displayName	SPHK1 binds PKR
eventOf	[Pathway:R-MMU-9833482] PKR-mediated signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9836606] SPHK1 binds PKR - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-168699] EIF2AK2 [cytosol] [EntityWithAccessionedSequence:R-MMU-5218716] phospho-p-S225-SPHK1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SPHK1 binds PKR
output	[Complex:R-MMU-9836608] EIF2AK2:p-SPHK1 [cytosol]
precedingEvent	[Reaction:R-MMU-5218823] PKC phosphorylates sphingosine kinase 1 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9836606
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-9833482] PKR-mediated signaling
(inferredTo)	[Reaction:R-HSA-9836606] SPHK1 binds PKR