Reactome | p-PKR dimer phosphorylates HIV tat

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p-PKR dimer phosphorylates HIV tat Show undefined attributes

authored	[InstanceEdit:9836445] Stephan, Ralf, 2023-05-28
catalystActivity	[CatalystActivity:9835964] protein kinase activity of p-EIF2AK2 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9836457] Stephan, Ralf, 2023-05-28
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	9836449
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	p-PKR dimer phosphorylates HIV tat
edited	[InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
eventOf	[Pathway:R-HSA-9833482] PKR-mediated signaling - Homo sapiens
input	5 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HIV-9836459] tat [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9835894] The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR [LiteratureReference:9836458] p53-derived host restriction of HIV-1 replication by protein kinase R-mediated Tat phosphorylation and inactivation [LiteratureReference:9838953] Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription
maxDepth	1
modified	[InstanceEdit:9937069] Stephan, Ralf, 2025-01-29
name	p-PKR dimer phosphorylates HIV tat
output	5 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HIV-9836453] p-T23,T40,S46,S62,S68-tat [cytosol]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9841953] Patel, Rekha C, 2023-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9836449
summation	[Summation:9836460] Activated protein kinase R (PKR, EIF2AK2) phosphorylates HIV...

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(hasEvent)

[Pathway:R-HSA-9833482] PKR-mediated signaling

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