p-PKR dimer phosphorylates HIV tat

Stable Identifier
R-HSA-9836449
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol
ReviewStatus
5/5
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p-PKR dimer phosphorylates HIV tat
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Activated protein kinase R (PKR, EIF2AK2) phosphorylates HIV tat on T23, T40, S46, S62, and S68, preventing nuclear localization of viral tat, disrupting its binding to TAR RNA, and inhibiting its interaction with cyclin T1 (Brand et al, 1997; Yoon et al, 2015). However, there are contradictory findings on tat ability to bind TAR after phosphorylation (Endo-Munoz et al, 2005).
Literature References
PubMed ID Title Journal Year
15737233 Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription

Harrich, D, Warby, T, McMillan, NA, Endo-Munoz, L

Virol J 2005
25653431 p53-derived host restriction of HIV-1 replication by protein kinase R-mediated Tat phosphorylation and inactivation

Bae, YS, Kim, SY, Byeon, SE, Yoon, CH, Park, J, Kim, KP, Lee, J, Jeong, Y

J Virol 2015
9079663 The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR

Brand, SR, Kobayashi, R, Mathews, MB

J Biol Chem 1997
Participants
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Output
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as an event of
Catalyst Activity

protein kinase activity of p-EIF2AK2 dimer [cytosol]

Physical Entity
p-EIF2AK2 dimer [cytosol] (Homo sapiens)
Activity
protein kinase activity (GO:0004672)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Stephan, R  (2023-05-28)
Reviewed
Patel, RC  (2023-08-16)
Created
Stephan, R  (2023-05-28)
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