Reactome | HIV Tat72 binds PKR

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HIV Tat72 binds PKR Show undefined attributes

authored	[InstanceEdit:9835455] Stephan, Ralf, 2023-05-15
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9835967] Stephan, Ralf, 2023-05-22
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	9835949
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	HIV Tat72 binds PKR
edited	[InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
eventOf	[Pathway:R-HSA-9833482] PKR-mediated signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-168699] EIF2AK2 [cytosol] [EntityWithAccessionedSequence:R-HIV-9835890] tat72 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9835930] HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms [LiteratureReference:9835894] The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR [LiteratureReference:9835907] Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: kinase signaling and PKR-mediated immune response [LiteratureReference:9841991] HIV-1 Tat directly interacts with the interferon-induced, double-stranded RNA-dependent kinase, PKR
maxDepth	1
modified	[InstanceEdit:9937069] Stephan, Ralf, 2025-01-29
name	HIV Tat72 binds PKR
output	[Complex:R-HSA-9835916] tat72:EIF2AK2 [cytosol]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9841953] Patel, Rekha C, 2023-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9835949
summation	[Summation:9835871] The relative amounts of the full length HIV protein Tat (Tat...

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[Pathway:R-HSA-9833482] PKR-mediated signaling

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