HIV Tat72 binds PKR

Stable Identifier
R-HSA-9835949
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol
ReviewStatus
5/5
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HIV Tat72 binds PKR
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The relative amounts of the full length HIV protein Tat (Tat86) and the short, cytosolic, single-exon Tat isoform (Tat72), both produced during HiV infection, vary depending on the cell type and the stage of infection. Tat72 binds to PKR, inhibiting its activation, thereby ensuring unhindered cellular protein translation during HIV-1 infection (McMillan et al, 1995; Brand et al, 1997; Cai et al, 2000; Li et al, 2005).
Literature References
PubMed ID Title Journal Year
10620360 HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms

Cai, R, Williams, BR, Jeang, KT, Carpick, B, Chun, RF

Arch Biochem Biophys 2000
15907845 Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: kinase signaling and PKR-mediated immune response

Cheung, BK, Lee, DC, Li, JC, Lau, AS

FEBS Lett 2005
7491766 HIV-1 Tat directly interacts with the interferon-induced, double-stranded RNA-dependent kinase, PKR

Siderovski, DP, Hovanessian, AG, McMillan, NA, Williams, BR, Jeang, KT, Galabru, J, Samuel, CE, Chun, RF, Mak, TW, Toone, WM

Virology 1995
9079663 The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR

Brand, SR, Kobayashi, R, Mathews, MB

J Biol Chem 1997
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Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Stephan, R  (2023-05-15)
Reviewed
Patel, RC  (2023-08-16)
Created
Stephan, R  (2023-05-22)
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