Reactome | Transfer of ubiquitin from E1 to E2

Transfer of ubiquitin from E1 to E2

Stable Identifier

R-HSA-983152

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Activated ubiquitin is transferred from E1 to the active site cystine of ubiquitin conjugating enzymes (E2s) via a trans-esterification reaction. E2s catalyze covalent attachment of ubiquitin to target proteins. They all share an active-site ubiquitin-binding cysteine residue and are distinguished by the presence of a ubiquitin-conjugating catalytic (UBC) fold required for binding of distinct ubiquitin ligases or E3s. Once conjugated to ubiquitin, the E2 molecule binds one of several E3s (Glickman et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
19940261	The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins van Wijk, SJ, Timmers, HT	FASEB J	2010
19851334	Building ubiquitin chains: E2 enzymes at work Ye, Y, Rape, M	Nat Rev Mol Cell Biol	2009
19452197	What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? Michelle, C, Vourc'h, P, Mignon, L, Andres, CR	J Mol Evol	2009