Production of type I IFN genes in response to Toll-like rece...

created [InstanceEdit:9828202] Shamovsky, Veronica, 2023-02-10
dbId 9828210
displayName Production of type I IFN genes in response to Toll-like rece...
literatureReference
modified [InstanceEdit:9863253] Shamovsky, Veronica, 2024-02-28
schemaClass Summation
text Production of type I IFN genes in response to Toll-like receptor 3 (TLR3) and TLR4 ligands is mediated by TANK-binding kinase 1 (TBK1) or I-kappa-B kinase epsilon (IKK?, IKBKE), which phosphorylate IFN regulatory factor 3 (IRF3) and IRF7. The activity of TBK1 and/or IRF3, IRF7 is regulated by multiple mechanisms including post-translational modifications, protein-protein interactions, and protein degradation (Zhao W et al., 2013; Runde AP et al., 2022).

This Reactome module describes regulation of TBK1, IKK? activity by K63-linked ubiquitination of TBK1 and IKK?, and TBK1 interaction with OPTN.

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