MITF-M-dependent DCT gene expression

Stable Identifier
R-HSA-9824586
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, melanosome membrane
ReviewStatus
5/5
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MITF-M-dependent DCT gene expression
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DCT (also known as TYRP2) encodes L-dopachrome tautomerase, an enzyme involved in melanin biosynthesis that converts L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (Jackson et al, 1992; Tsukamoto et al, 1992; Pennamen et al, 2021; Bouchard et al, 1994; reviewed in Cheli et al, 2010). Expression of DCT during melanogenesis is initially repressed through the combined actions of PAX3, LEF1 and TLE4 (Yasumoto et al, 2002; Ludwig et al, 2002; Lang et al, 2005). This repressive complex is replaced by MITF-M and SOX10 binding to cognate elements in the promoter concurrent with the recruitment of CTNNB1 in place of TLE4 (Yasumoto et al, 2002; Ludwig et al, 2002; Saito et al, 2002; Saito et al, 2003; Lang et al, 2005; reviewed in Cheli et al, 2010).
Literature References
PubMed ID Title Journal Year
12048204 Melanocyte-specific microphthalmia-associated transcription factor isoform activates its own gene promoter through physical interaction with lymphoid-enhancing factor 1

Saito, H, Yasumoto, K, Takeda, K, Takahashi, K, Fukuzaki, A, Orikasa, S, Shibahara, S

J Biol Chem 2002
15729346 Pax3 functions at a nodal point in melanocyte stem cell differentiation

Lang, D, Lu, MM, Huang, L, Engleka, KA, Zhang, M, Chu, EY, Lipner, S, Skoultchi, A, Millar, SE, Epstein, JA

Nature 2005
12753399 Microphthalmia-associated transcription factor in the Wnt signaling pathway

Saito, H, Yasumoto, K, Takeda, K, Takahashi, K, Yamamoto, H, Shibahara, S

Pigment Cell Res 2003
12032083 Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling

Yasumoto, K, Takeda, K, Saito, H, Watanabe, K, Takahashi, K, Shibahara, S

EMBO J 2002
33100333 Dopachrome tautomerase variants in patients with oculocutaneous albinism

Pennamen, P, Tingaud-Sequeira, A, Gazova, I, Keighren, M, McKie, L, Marlin, S, Gherbi Halem, S, Kaplan, J, Delevoye, C, Lacombe, D, Plaisant, C, Michaud, V, Lasseaux, E, Javerzat, S, Jackson, I, Arveiler, B

Genet Med 2021
19995375 Fifteen-year quest for microphthalmia-associated transcription factor target genes

Cheli, Y, Ohanna, M, Ballotti, R, Bertolotto, C

Pigment Cell Melanoma Res 2010
8306979 Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells

Bouchard, B, Del Marmol, V, Jackson, IJ, Cherif, D, Dubertret, L

Eur. J. Biochem. 1994
1537334 A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus

Jackson, IJ, Chambers, DM, Tsukamoto, K, Copeland, NG, Gilbert, DJ, Jenkins, NA, Hearing, V

EMBO J 1992
14706856 Melanocyte-specific expression of dopachrome tautomerase is dependent on synergistic gene activation by the Sox10 and Mitf transcription factors

Ludwig, A, Rehberg, S, Wegner, M

FEBS Lett 2004
1537333 A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase

Tsukamoto, K, Jackson, IJ, Urabe, K, Montague, PM, Hearing, VJ

EMBO J. 1992
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:SOX10:p-S133 CREB1:LEF1:CTNNB1:DCT gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
CTNNB1 [nucleoplasm]
SOX10 [nucleoplasm]
Authored
Rothfels, K  (2023-01-26)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2023-01-20)
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