Reactome | OPTN binds TBK1 within the activated TLR4 complex

Schema > Reaction > Entries

OPTN binds TBK1 within the activated TLR4 complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10093616
displayName	OPTN binds TBK1 within the activated TLR4 complex
eventOf	[Pathway:R-MMU-9824878] Regulation of TBK1, IKK? (IKBKE)-mediated activation of IRF3, IRF7 - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9823934] OPTN binds TBK1 within the activated TLR4 complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-9687907] OPTN [cytosol] [Complex:R-MMU-9823899] TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	OPTN binds TBK1 within the activated TLR4 complex
output	[Complex:R-MMU-9823935] OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane]
precedingEvent	[Reaction:R-MMU-9823910] Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9823934
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9824878] Regulation of TBK1, IKK? (IKBKE)-mediated activation of IRF3, IRF7
(inferredTo)	[Reaction:R-HSA-9823934] OPTN binds TBK1 within the activated TLR4 complex

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