Reactome | Expression of GATA4 in definitive endoderm

Schema > BlackBoxEvent > Entries

Expression of GATA4 in definitive endoderm Show undefined attributes

authored	[InstanceEdit:9823866] May, Bruce, 2023-01-11
category	uncertain
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9823835] May, Bruce, 2023-01-11
dbId	9823849
displayName	Expression of GATA4 in definitive endoderm
edited	[InstanceEdit:9823866] May, Bruce, 2023-01-11
eventOf	[Pathway:R-HSA-9823730] Formation of definitive endoderm - Homo sapiens
followingEvent	[Reaction:R-HSA-9824472] TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9823863] Expression of Gata4 in definitive endoderm - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-9733696] GATA4 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2888922] Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors [LiteratureReference:9823982] GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation [LiteratureReference:9825100] Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed [LiteratureReference:9825097] Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways
maxDepth	1
modified	[InstanceEdit:9830227] May, Bruce, 2023-02-28
name	Expression of GATA4 in definitive endoderm
output	[EntityWithAccessionedSequence:R-HSA-400553] GATA4 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9796209] Expression of FOXA2 in the anterior primitive streak - Homo sapiens [Reaction:R-HSA-9823836] SMAD2,3, FOXA2, TBXT, and GATA6 bind the GATA4 gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9823851] Positive gene expression regulation by 'p-2S-SMAD2,3:SMAD4:FOXA2:TBXT:GATA6:GATA4 gene [nucleoplasm]'
releaseDate	2023-03-29
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9830224] Salehin, Nazmus, 2023-02-28 [InstanceEdit:9830223] Tam, Patrick P L, 2023-02-28
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9823849
summation	[Summation:9825111] GATA4 is expressed in visceral endoderm and definitive endod...

Referrals

(hasEvent)	[Pathway:R-HSA-9823730] Formation of definitive endoderm
(precedingEvent)	[Reaction:R-HSA-9824472] TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene
(inferredTo)	[BlackBoxEvent:R-MMU-9823863] Expression of Gata4 in definitive endoderm