Expression of GATA4 in definitive endoderm

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Reaction [uncertain]
Homo sapiens
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GATA4 is expressed in visceral endoderm and definitive endoderm and subsequently is enriched in the mid and posterior gut (inferred from mouse embryos in Arceci et al. 1993, Rojas et al. 2009, Rojas et al. 2010). Expression of GATA4 is activated by NODAL signaling (McLean et al. 2007, Vallier et al. 2009) through the binding of phosphorylated SMAD2 and SMAD3 to the GATA4 promoter (inferred from human pluripotent stem cells in Brown et al. 2011, Chia et al. 2019). FOXA2 (inferred from mouse homologs) and GATA6 (Chia et al. 2019), other key regulators of endoderm formation, also bind the GATA4 promoter and activate GATA4 transcription.
Literature References
PubMed ID Title Journal Year
19564924 Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways

Weber, A, Pedersen, RA, Chng, Z, Vallier, L, Hannan, N, Rugg-Gunn, P, Smithers, LE, Touboul, T, Millan, E, Trotter, M, Brimpari, M

PLoS One 2009
30629940 GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation

Dunn, NR, Garcia-Bernardo, J, Chia, CY, Hattersley, AT, Madrigal, P, Vallier, L, Chhatriwala, M, Denil, SLIJ, El-Khairi, R, Shepherd, MH, Martinez, I

Stem Cell Reports 2019
17204604 Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed

Xu, Y, McLean, AB, Dalton, S, Liu, H, Kulik, MJ, D'Amour, KA, Sheppard, AM, Krishnamoorthy, M, Baetge, EE, Reynolds, DM, Jones, KL

Stem Cells 2007
21630377 Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors

Dunn, NR, Lim, B, Cho, CH, Vallier, L, Pedersen, R, Hannan, N, Teo, A, Vardy, L, Brown, S, Trotter, M, Pauklin, S

Stem Cells 2011
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