Reactome | KDM5A demethylates histone H3 trimethyllysine-4 (H3K4me3)

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KDM5A demethylates histone H3 trimethyllysine-4 (H3K4me3) Show undefined attributes

authored	[InstanceEdit:9822440] May, Bruce, 2022-12-23
catalystActivity	[CatalystActivity:9822465] histone H3K4 demethylase activity of KDM5A:Fe2+ [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9822458] May, Bruce, 2022-12-24
dbId	9822467
displayName	KDM5A demethylates histone H3 trimethyllysine-4 (H3K4me3)
edited	[InstanceEdit:9822440] May, Bruce, 2022-12-23
eventOf	[Pathway:R-HSA-9821002] Chromatin modifications during the maternal to zygotic transition (MZT) - Homo sapiens
inferredFrom	[Reaction:R-MMU-9822463] Kdm5a demethylates histone H3 trimethyllysine-4 (H3K4me3) - Mus musculus
input	3 × [SimpleEntity:R-ALL-113671] 2OG [nucleoplasm] [DefinedSet:R-HSA-1214232] Histone H3 (H3K4me3) [nucleoplasm] 3 × [SimpleEntity:R-ALL-113685] O2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:4687056] The retinoblastoma binding protein RBP2 is an H3K4 demethylase [LiteratureReference:4687087] RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3 [LiteratureReference:4687054] The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases
maxDepth	1
modified	[InstanceEdit:9841067] May, Bruce, 2023-08-08
name	KDM5A demethylates histone H3 trimethyllysine-4 (H3K4me3)
output	3 × [SimpleEntity:R-ALL-29478] CH2O [nucleoplasm] 3 × [SimpleEntity:R-ALL-159942] CO2 [nucleoplasm] [DefinedSet:R-HSA-212293] Histone H3 [nucleoplasm] 3 × [SimpleEntity:R-ALL-159939] SUCCA [nucleoplasm]
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9841065] Xie, Wei, 2023-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9822467
summation	[Summation:9822580] The histone demethylase KDM5A (JARID1A, RBBP2, RBP2) demethy...

Referrals

(hasEvent)	[Pathway:R-HSA-9821002] Chromatin modifications during the maternal to zygotic transition (MZT)
(inferredTo)	[Reaction:R-MMU-9822463] Kdm5a demethylates histone H3 trimethyllysine-4 (H3K4me3)

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