KDM5A demethylates histone H3 trimethyllysine-4 (H3K4me3)

Stable Identifier
R-HSA-9822467
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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KDM5A demethylates histone H3 trimethyllysine-4 (H3K4me3)
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The histone demethylase KDM5A (JARID1A, RBBP2, RBP2) demethylates trimethylated histone 3 lysine-4 (H3K4me3, lysine-5 of the preprotein) in in vitro and in embryonic stem cells (Christensen et al. 2007, Iwase et al. 2077, Klose et al. 2007) and is inferred to catalyze the same reaction in zygotes. KDM5A can processively remove all three methyl groups to yield unmethylated H3K4 (Christensen et al. 2007, Klose et al. 2007), however other studies showed demethylation of H3K4me3 to H3K4me2 and H3K4me1 (Iwase et al. 2007). In 2-cell embryos, nucleosomes contain a canonical distrubution of H3.1, H3.2, and H3.3 (inferred from mouse embryos). KDM5A and KDM5B are responsible for demethylating the broad regions of H3K4me3 that are inherited from oocytes (inferred from mouse embryos). The result is peaks of H3K4me3 at the 5' and 3' ends of genes.
Literature References
PubMed ID Title Journal Year
17320160 The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases

Iwase, S, Lan, F, Bayliss, P, de la Torre-Ubieta, L, Huarte, M, Qi, HH, Whetstine, JR, Bonni, A, Roberts, TM, Shi, Y

Cell 2007
17320161 RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3

Christensen, J, Agger, K, Cloos, PA, Pasini, D, Rose, S, Sennels, L, Rappsilber, J, Hansen, KH, Salcini, AE, Helin, K

Cell 2007
17320163 The retinoblastoma binding protein RBP2 is an H3K4 demethylase

Klose, RJ, Yan, Q, Tothova, Z, Yamane, K, Erdjument-Bromage, H, Tempst, P, Gilliland, DG, Zhang, Y, Kaelin, WG

Cell 2007
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as an event of
Catalyst Activity

histone H3K4 demethylase activity of KDM5A:Fe2+ [nucleoplasm]

Physical Entity
KDM5A:Fe2+ [nucleoplasm] (Homo sapiens)
Activity
histone H3K4 demethylase activity (GO:0032453)
Inferred From
Kdm5a demethylates histone H3 trimethyllysine-4 (H3K4me3) (Mus musculus)
Authored
May, B  (2022-12-23)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-12-24)
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