Reactome | DIS3L2 hydrolyzes uridylated mRNA

Schema > BlackBoxEvent > Entries

authored	[InstanceEdit:9822429] May, Bruce, 2022-12-23
catalystActivity	[CatalystActivity:9822434] 3'-5'-RNA exonuclease activity of DIS3L2:PABPN1:uridylated partially deadenylated mRNA complex [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9822431] May, Bruce, 2022-12-23
dbId	9822437
displayName	DIS3L2 hydrolyzes uridylated mRNA
edited	[InstanceEdit:9822429] May, Bruce, 2022-12-23
eventOf	[Pathway:R-HSA-9820865] Z-decay: degradation of maternal mRNAs by zygotically expressed factors - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9822432] Dis3l2 hydrolyzes uridylated mRNA - Mus musculus
input	[Complex:R-HSA-9820886] DIS3L2:PABPN1:uridylated partially deadenylated mRNA complex [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9841067] May, Bruce, 2023-08-08
name	DIS3L2 hydrolyzes uridylated mRNA
output	[EntityWithAccessionedSequence:R-HSA-9820867] DIS3L2 [cytosol] [EntityWithAccessionedSequence:R-HSA-9822424] PABPN1 [cytosol]
precedingEvent	[Reaction:R-HSA-9820895] DIS3L2 binds PABPN1 in PABPN1:uridylated mRNA complex - Homo sapiens
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9841065] Xie, Wei, 2023-08-08
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9822437
summation	[Summation:9822436] PABPN1 bound to 3' uridylated mRNA recruits DIS3L2, an exoso...

(hasEvent)	[Pathway:R-HSA-9820865] Z-decay: degradation of maternal mRNAs by zygotically expressed factors
(inferredTo)	[BlackBoxEvent:R-MMU-9822432] Dis3l2 hydrolyzes uridylated mRNA

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