DIS3L2 hydrolyzes uridylated mRNA

Stable Identifier
R-HSA-9822437
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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DIS3L2 hydrolyzes uridylated mRNA
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PABPN1 bound to 3' uridylated mRNA recruits DIS3L2, an exosome-independent 3'-5' exoribonuclease that degrades the mRNA (inferred from mouse homologs).
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Catalyst Activity

3'-5'-RNA exonuclease activity of DIS3L2:PABPN1:uridylated partially deadenylated mRNA complex [cytosol]

Physical Entity
DIS3L2:PABPN1:uridylated partially deadenylated mRNA complex [cytosol] (Homo sapiens)
Activity
3'-5'-RNA exonuclease activity (GO:0000175)
Inferred From
Dis3l2 hydrolyzes uridylated mRNA (Mus musculus)
Authored
May, B  (2022-12-23)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-12-23)
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