Reactome | Replacement of protamines by nucleosomes in the male pronucleus

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Replacement of protamines by nucleosomes in the male pronucleus Show undefined attributes

authored	[InstanceEdit:9821962] May, Bruce, 2022-12-12
created	[InstanceEdit:9821985] May, Bruce, 2022-12-16
dbId	9821993
displayName	Replacement of protamines by nucleosomes in the male pronucleus
edited	[InstanceEdit:9821962] May, Bruce, 2022-12-12
eventOf	[Pathway:R-HSA-9816359] Maternal to zygotic transition (MZT) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:2588007] epigenetic programming in the zygotic pronuclei
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9821982] SRPK1 phosphorylates PRM1 in PRM1:dsDNA - Homo sapiens [Reaction:R-HSA-9821967] SRPK1 phosphorylates PRM2 in PRM2:dsDNA - Homo sapiens [Reaction:R-HSA-9822117] NPM2 and HIRA bind p-S9-PRM1:dsDNA - Homo sapiens [BlackBoxEvent:R-HSA-9822115] NPM2 dissociates p-S9-PRM1 from HIRA:NPM2:p-S9-PRM1:dsDNA - Homo sapiens [Reaction:R-HSA-9822583] METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein) - Homo sapiens [BlackBoxEvent:R-HSA-9822185] HIRA and NPM2 assemble H3.3-containing nucleosomes on paternal DNA - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9822184] Epigenetic modifications and reprogramming in paternal pronucleus: sperm, preimplantation embryo, and beyond [LiteratureReference:9821458] Maternal histone variants and their chaperones promote paternal genome activation and boost somatic cell reprogramming [LiteratureReference:9822200] Functional Aspects of Sperm Chromatin Organization [LiteratureReference:9821954] Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation [LiteratureReference:9822111] Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling [LiteratureReference:9822216] The roles of histone variants in fine-tuning chromatin organization and function [LiteratureReference:9822255] The Oocyte-Specific Linker Histone H1FOO Is Not Essential for Mouse Oogenesis and Fertility [LiteratureReference:9822600] Histone H3 Methylated at Arginine 17 Is Essential for Reprogramming the Paternal Genome in Zygotes [LiteratureReference:9823272] The Interplay Between Replacement and Retention of Histones in the Sperm Genome [LiteratureReference:9841033] Epigenetic marking of sperm by post-translational modification of histones and protamines [LiteratureReference:9841029] Characterization of linker histone H1FOO during bovine in vitro embryo development
maxDepth	2
modified	[InstanceEdit:9841067] May, Bruce, 2023-08-08
name	Replacement of protamines by nucleosomes in the male pronucleus
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9841065] Xie, Wei, 2023-08-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9821993
summation	[Summation:9822230] In human sperm, about 85 to 90% of the genome is associated ...

Referrals

(hasEvent)

[Pathway:R-HSA-9816359] Maternal to zygotic transition (MZT)

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