Reactome | NPM2 and HIRA bind p-S9-PRM1:dsDNA

Schema > Reaction > Entries

authored	[InstanceEdit:9822112] May, Bruce, 2022-12-18
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9822122] May, Bruce, 2022-12-19
dbId	9822117
displayName	NPM2 and HIRA bind p-S9-PRM1:dsDNA
edited	[InstanceEdit:9822112] May, Bruce, 2022-12-18
eventOf	[Pathway:R-HSA-9821993] Replacement of protamines by nucleosomes in the male pronucleus - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9822115] NPM2 dissociates p-S9-PRM1 from HIRA:NPM2:p-S9-PRM1:dsDNA - Homo sapiens
inferredFrom	[Reaction:R-MMU-9822106] Npm2 and Hira bind p-S9,S43-Prm1:dsDNA - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-2532790] HIRA [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9821980] NPM2 [nucleoplasm] [Complex:R-HSA-9821979] p-S9-PRM1:dsDNA [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9841067] May, Bruce, 2023-08-08
name	NPM2 and HIRA bind p-S9-PRM1:dsDNA
output	[Complex:R-HSA-9822109] HIRA:NPM2:p-S9-PRM1:dsDNA [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9821982] SRPK1 phosphorylates PRM1 in PRM1:dsDNA - Homo sapiens
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9841065] Xie, Wei, 2023-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9822117
summation	[Summation:9822182] NPM2 and HIRA bind phosphorylated PRM1 (inferred from mouse ...

(precedingEvent)	[BlackBoxEvent:R-HSA-9822115] NPM2 dissociates p-S9-PRM1 from HIRA:NPM2:p-S9-PRM1:dsDNA
(hasEvent)	[Pathway:R-HSA-9821993] Replacement of protamines by nucleosomes in the male pronucleus
(inferredTo)	[Reaction:R-MMU-9822106] Npm2 and Hira bind p-S9,S43-Prm1:dsDNA

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