Reactome | C3 convertases spontaneously dissociate

Schema > Reaction > Entries

C3 convertases spontaneously dissociate Show undefined attributes

authored	[InstanceEdit:981647] Jupe, S, 2010-10-26
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:981647] Jupe, S, 2010-10-26
dbId	981621
displayName	C3 convertases spontaneously dissociate
edited	[InstanceEdit:983442] Jupe, S, 2010-11-01
eventOf	[Pathway:R-HSA-977606] Regulation of Complement cascade - Homo sapiens
input	[DefinedSet:R-HSA-173750] C3 convertases [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:182540] Alternative pathway of complement: recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of the pathway [LiteratureReference:981688] The human complement system: assembly of the classical pathway C3 convertase
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	C3 convertases spontaneously dissociate
orthologousEvent	[Reaction:R-XTR-981621] C3 convertases spontaneously dissociate - Xenopus tropicalis [Reaction:R-DRE-981621] C3 convertases spontaneously dissociate - Danio rerio [Reaction:R-SSC-981621] C3 convertases spontaneously dissociate - Sus scrofa [Reaction:R-BTA-981621] C3 convertases spontaneously dissociate - Bos taurus [Reaction:R-CFA-981621] C3 convertases spontaneously dissociate - Canis familiaris [Reaction:R-MMU-981621] C3 convertases spontaneously dissociate - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-166780] C2a [extracellular region] [Complex:R-HSA-182450] C3(H2O) [extracellular region] 3 × [Complex:R-HSA-166832] C3b [extracellular region] [Complex:R-HSA-981716] Cell surface:C4b [plasma membrane] [Complex:R-HSA-166784] Cell surface:C4b:C2a [plasma membrane] 3 × [EntityWithAccessionedSequence:R-HSA-182453] CFB(260-764) [extracellular region] [Polymer:R-HSA-182548] Properdin oligomer [extracellular region]
precedingEvent	[Reaction:R-HSA-166795] Formation of Classical C3 convertase (C4b:C2a complex) - Homo sapiens [Reaction:R-HSA-174551] Formation of alternative pathway C5 convertase - Homo sapiens [Reaction:R-HSA-173636] Formation of classic pathway C5 convertase - Homo sapiens [Reaction:R-HSA-173754] Properdin stabilizes C3b:Bb bound to cell surfaces - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2109568] Bradley, DT, 2012-02-13 [InstanceEdit:2109566] Fraczek, LA, 2012-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-981621
summation	[Summation:981627] C3b:Bb is naturally labile with a half-life of ~90 s. unless...
updateTrackers	[UpdateTracker:9788490] Update Tracker - [Reaction:981621] C3 convertases spontaneously dissociate - v42:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9788490] Update Tracker - [Reaction:981621] C3 convertases spontaneously dissociate - v42:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-977606] Regulation of Complement cascade