Reactome | C3 convertases spontaneously dissociate

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C3 convertases spontaneously dissociate Show undefined attributes

category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10372670
displayName	C3 convertases spontaneously dissociate
eventOf	[Pathway:R-BTA-977606] Regulation of Complement cascade - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-981621] C3 convertases spontaneously dissociate - Homo sapiens
input	[DefinedSet:R-BTA-173750] C3 convertases [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	C3 convertases spontaneously dissociate
output	[EntityWithAccessionedSequence:R-BTA-166780] C2a [extracellular region] [Complex:R-BTA-182450] C3(H2O) [extracellular region] 3 × [Complex:R-BTA-166832] C3b [extracellular region] [Complex:R-BTA-981716] Cell surface:C4b [plasma membrane] [Complex:R-BTA-166784] Cell surface:C4b:C2a [plasma membrane] 3 × [EntityWithAccessionedSequence:R-BTA-182453] CFB(260-764) [extracellular region] [Polymer:R-BTA-182548] Properdin oligomer [extracellular region]
precedingEvent	[Reaction:R-BTA-166795] Formation of Classical C3 convertase (C4b:C2a complex) - Bos taurus [Reaction:R-BTA-174551] Formation of alternative pathway C5 convertase - Bos taurus [Reaction:R-BTA-173636] Formation of classic pathway C5 convertase - Bos taurus [Reaction:R-BTA-173754] Properdin stabilizes C3b:Bb bound to cell surfaces - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-981621
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-977606] Regulation of Complement cascade
(inferredTo)	[Reaction:R-HSA-981621] C3 convertases spontaneously dissociate