Reactome | RB1 and TFAP2A bind CDH1 gene promoter

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RB1 and TFAP2A bind CDH1 gene promoter Show undefined attributes

authored	[InstanceEdit:9768289] Orlic-Milacic, Marija, 2022-03-04
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9768289] Orlic-Milacic, Marija, 2022-03-04
dbId	9768288
displayName	RB1 and TFAP2A bind CDH1 gene promoter
edited	[InstanceEdit:9930641] Orlic-Milacic, Marija, 2024-12-04
eventOf	[Pathway:R-HSA-9764790] Positive Regulation of CDH1 Gene Transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9768293] RB1 and TFAP2A stimulate CDH1 gene transcription - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9756422] CDH1 gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-68642] RB1 [nucleoplasm] [Complex:R-HSA-8864382] TFAP2A homodimer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9768291] Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition [LiteratureReference:9768445] Loss of AP-2alpha results in deregulation of E-cadherin and MMP-9 and an increase in tumorigenicity of colon cancer cells in vivo [LiteratureReference:9768544] The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2 [LiteratureReference:9768541] RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2
maxDepth	1
modified	[InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
name	RB1 and TFAP2A bind CDH1 gene promoter
output	[Complex:R-HSA-9794242] RB1:TFAP2A homodimer:CDH1 gene [nucleoplasm]
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9768288
summation	[Summation:9794227] The retinoblastoma tumor suppressor protein RB1 and the tran...

Referrals

(hasEvent)	[Pathway:R-HSA-9764790] Positive Regulation of CDH1 Gene Transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-9768293] RB1 and TFAP2A stimulate CDH1 gene transcription