Reactome | GSK3B phosphorylates p-NFE2L2

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GSK3B phosphorylates p-NFE2L2 Show undefined attributes

authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
catalystActivity	[CatalystActivity:2022841] protein serine/threonine kinase activity of GSK3B [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9762099] Rothfels, Karen, 2022-01-17
dbId	9762094
displayName	GSK3B phosphorylates p-NFE2L2
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
eventOf	[Pathway:R-HSA-9762114] GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 - Homo sapiens
followingEvent	[Reaction:R-HSA-9762093] BTRC binds p-S344, 347 NFE2L2 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [CandidateSet:R-HSA-9708562] p-NFE2L2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway [LiteratureReference:9762027] The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis [LiteratureReference:9761948] Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2 [LiteratureReference:9761995] SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner [LiteratureReference:9762014] Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/?-TrCP axis [LiteratureReference:9762004] Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3 [LiteratureReference:9761972] Nrf2 is controlled by two distinct ?-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	GSK3B phosphorylates p-NFE2L2
orthologousEvent	[Reaction:R-CEL-9762094] GSK3B phosphorylates p-NFE2L2 - Caenorhabditis elegans [Reaction:R-DME-9762094] GSK3B phosphorylates p-NFE2L2 - Drosophila melanogaster [Reaction:R-GGA-9762094] GSK3B phosphorylates p-NFE2L2 - Gallus gallus [Reaction:R-XTR-9762094] GSK3B phosphorylates p-NFE2L2 - Xenopus tropicalis [Reaction:R-DRE-9762094] GSK3B phosphorylates p-NFE2L2 - Danio rerio [Reaction:R-SSC-9762094] GSK3B phosphorylates p-NFE2L2 - Sus scrofa [Reaction:R-BTA-9762094] GSK3B phosphorylates p-NFE2L2 - Bos taurus [Reaction:R-CFA-9762094] GSK3B phosphorylates p-NFE2L2 - Canis familiaris [Reaction:R-RNO-9762094] GSK3B phosphorylates p-NFE2L2 - Rattus norvegicus [Reaction:R-MMU-9762094] GSK3B phosphorylates p-NFE2L2 - Mus musculus
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [CandidateSet:R-HSA-9762061] p-S344, 347 NFE2L2 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-8932309] NFE2L2 translocates from cytosol to nucleoplasm - Homo sapiens
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9762094
summation	[Summation:9762074] GSK3B promotes the nuclear, KEAP1-independent degradation of...

Referrals

(hasEvent)	[Pathway:R-HSA-9762114] GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
(precedingEvent)	[Reaction:R-HSA-9762093] BTRC binds p-S344, 347 NFE2L2

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