Reactome | TRIM21 ubiquitinates SQSTM1

TRIM21 ubiquitinates SQSTM1

Stable Identifier

R-HSA-9759154

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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E3 ubiquitin ligase TRIM21 ubiquitinates SQSTM1 at lysine 7, inhibiting SQSTM1 oligomerization and therefore its ability to sequester and degrade ubiquitinated proteins (Pan et al, 2016). Among the proteins targeted by SQSTM1 is KEAP1, a negative regulator of redox response through KEAP1-mediated degradation of NFE2L2 (reviewed in Baird and Yamamoto, 2020).

Literature References

PubMed ID	Title	Journal	Year
32284348	The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway Baird, L, Yamamoto, M	Mol Cell Biol	2020
26942676	TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis Pan, JA, Sun, Y, Jiang, YP, Bott, AJ, Jaber, N, Dou, Z, Yang, B, Chen, JS, Catanzaro, JM, Du, C, Ding, WX, Diaz-Meco, MT, Moscat, J, Ozato, K, Lin, RZ, Zong, WX	Mol Cell	2016